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Article

Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma.

Pediatric blood & cancer - 1 Oct 2015

Studebaker Adam, Bondra Kathryn, Seum Star, Shen Changxian, Phelps Doris A, Chronowski Christopher, Leasure Justin, Smith Paul D, Kurmasheva Raushan T, Mo Xiaokui, Fouladi Maryam, Houghton Peter J

Abstract excerpt

PURPOSE: Curative therapy for childhood glioma presents challenges when complete resection is not possible. Patients with recurrent low-grade tumors or anaplastic astrocytoma may receive radiation treatment; however, the long-term sequellae from radiation treatment can be severe. As many childhood gliomas are associated with activation of BRAF, we have explored the combination of ionizing radiation with MEK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25981859
DOI: 10.1002/pbc.25579
PMCID: PMC4561855

Genes

BRAF
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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