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Article

Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy

15 Aug 2013

Abstract excerpt

BACKGROUND: Androgen-deprivation therapy (ADT) is standard treatment for locally advanced or metastatic prostate cancer (PCa). Many patients develop castration resistance (castration-resistant PCa [CRPC]) after approximately 2-3 yr, with a poor prognosis. The molecular mechanisms underlying CRPC progression are unclear. OBJECTIVE: To undertake quantitative tumour transcriptome profiling prior to and following ADT...

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PMID: 24054872
DOI: 10.1016/j.eururo.2013.08.011

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