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Article

Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer

18 Sept 2015

Abstract excerpt

Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have investigated whether BTK is a potential therapeutic target in prostate cancer. We find that BTK is expressed in prostate cells, with the alternate BTK-C isoform predominantly expressed in prostate cancer cells and tumors. This isoform is transcribed from an alternative promoter and...

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PMID: 26383180
DOI: 10.1080/15384047.2015.1078023

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