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Article

Differential modulation of fast inactivation in cardiac sodium channel splice variants by Fyn tyrosine kinase.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2015

Iqbal Shahid M, Andavan Gowri S B, Lemmens-Gruber Rosa

Abstract excerpt

BACKGROUND/AIMS: Post-translational modifications such as phosphorylation and dephosphorylation can finely tune the function of ion channels. Nav1.5 is the main sodium channel in human hearts and alternative splicing of the transcript generates two major splice variants, characterized by the presence (Q-pre) or absence (Q-del) of glutamine at position 1077. In the heart, both the Nav1.5 channel and Fyn tyrosine...

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PMID: 26382759
DOI: 10.1159/000430211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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