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Article

Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns.

American journal of physiology. Cell physiology - 1 Mar 2010

Burg Elyssa D, Platoshyn Oleksandr, Tsigelny Igor F, Lozano-Ruiz Beatriz, Rana Brinda K, Yuan Jason X-J

Abstract excerpt

The activity of voltage-gated K(+) (K(V)) channels plays an important role in regulating pulmonary artery smooth muscle cell (PASMC) contraction, proliferation, and apoptosis. The highly conserved NH(2)-terminal tetramerization domain (T1) of K(V) channels is important for proper channel assembly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20018952
DOI: 10.1152/ajpcell.00464.2009
PMCID: PMC2838577

Genes

KCNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20018952-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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