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Article

Parkinson's disease: From human genetics to clinical trials.

Science translational medicine - 16 Sept 2015

van der Brug Marcel P, Singleton Andrew, Gasser Thomas, Lewis Patrick A

Abstract excerpt

Combining genetic insights into the pathogenesis of Parkinson's disease (PD) with findings from animal and cellular models of this disorder has advanced our understanding of the pathways that lead to the characteristic degeneration of dopaminergic neurons in the brain's nigrostriatal pathway. This has fueled an increase in candidate compounds designed to modulate these pathways and to alter the processes...

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Identifiers

PMID: 26378242
DOI: 10.1126/scitranslmed.aaa8280
PMCID: PMC5995146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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