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Article

Pharmacogenetics of pemetrexed combination therapy in lung cancer: pathway analysis reveals novel toxicity associations.

The pharmacogenomics journal - 1 Oct 2014

Corrigan A, Walker J L, Wickramasinghe S, Hernandez M A, Newhouse S J, Folarin A A, Lewis C M, Sanderson J D, Spicer J, Marinaki A M

Abstract excerpt

Identification of polymorphisms that influence pemetrexed tolerability could lead to individualised treatment regimens and improve quality of life. Twenty-eight polymorphisms within eleven candidate genes were genotyped using the Illumina Human Exome v1.1 BeadChip and tested for their association with the clinical outcomes of non-small cell lung cancer and mesothelioma patients receiving pemetrexed/platinum...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24732178
DOI: 10.1038/tpj.2014.13

Genes

DHFR
FOLR3
GGH

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