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Article

Gene-Gene Interactions of Gemcitabine Metabolizing-Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine-Induced Hematological Toxicity.

Journal of clinical pharmacology - 1 Oct 2021

Li Juan, Chen Bing, Xi Wen-Qi, Yang Chen, Zhang Wei-Xia

Abstract excerpt

Most patients experience severe hematological toxicity during treatment with gemcitabine; thus, preventing such toxicity would improve the treatment effects and patient quality of life. We analyzed 13 polymorphisms in the transporters, metabolizing enzymes, targets, and genes involved in DNA damage and the folate pathway among 132 patients treated with gemcitabine and studied their association with the severity...

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PMID: 33974709
DOI: 10.1002/jcph.1909

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