Article
Cre-Mediated Recombination in Tas2r131 Cells-A Unique Way to Explore Bitter Taste Receptor Function Inside and Outside of the Taste System.
Chemical senses - 1 Nov 2015
Voigt Anja, Hübner Sandra, Döring Linda, Perlach Nathalie, Hermans-Borgmeyer Irm, Boehm Ulrich, Meyerhof Wolfgang
Abstract excerpt
The type 2 taste receptors (Tas2rs) comprise a large family of G protein-coupled receptors that recognize compounds bitter to humans and aversive to vertebrates. Tas2rs are expressed in both gustatory and nongustatory tissues, however, identification and functional analyses of T2R-expressing cells have been difficult in most tissues. To overcome these limitations and to be able to manipulate Tas2r-expressing...
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