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Article

Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.

Development (Cambridge, England) - 1 Aug 2014

Castillo David, Seidel Kerstin, Salcedo Ernesto, Ahn Christina, de Sauvage Frederic J, Klein Ophir D, Barlow Linda A

Abstract excerpt

Taste buds are assemblies of elongated epithelial cells, which are innervated by gustatory nerves that transmit taste information to the brain stem. Taste cells are continuously renewed throughout life via proliferation of epithelial progenitors, but the molecular regulation of this process remains unknown. During embryogenesis, sonic hedgehog (SHH) negatively regulates taste bud patterning, such that inhibition...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24993944
DOI: 10.1242/dev.107631
PMCID: PMC4197660

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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