Article
Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B.
Animal models and experimental medicine - 1 Jun 2024
Niu Bowen, Liu Lingling, Gao Qian, Zhu Meng-Min, Chen Lixiang, Peng Xiu-Hua, Qin Boying, Zhou Xiaohui, Li Feng
Abstract excerpt
BACKGROUND: Bitter taste receptors (Tas2rs) are generally considered to sense various bitter compounds to escape the intake of toxic substances. Bitter taste receptors have been found to widely express in extraoral tissues and have important physiological functions outside the gustatory system in...
Topics
- Animals
- Receptors, G-Protein-Coupled
- Taste Perception
- Mice
- Mutation
- Quaternary Ammonium Compounds
- Taste Buds
- CRISPR-Cas Systems
- Taste
- Transducin
- Gene Editing
- Triterpenes
- Heterotrimeric GTP-Binding Proteins
- Phospholipase C beta
- Taste Receptors, Type 2