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Article

Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B.

Animal models and experimental medicine - 1 Jun 2024

Niu Bowen, Liu Lingling, Gao Qian, Zhu Meng-Min, Chen Lixiang, Peng Xiu-Hua, Qin Boying, Zhou Xiaohui, Li Feng

Abstract excerpt

BACKGROUND: Bitter taste receptors (Tas2rs) are generally considered to sense various bitter compounds to escape the intake of toxic substances. Bitter taste receptors have been found to widely express in extraoral tissues and have important physiological functions outside the gustatory system in vivo. METHODS: To investigate the physiological functions of the bitter taste receptor cluster...

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Source

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Identifiers

PMID: 38155461
DOI: 10.1002/ame2.12357
PMCID: PMC11228091

Genes

GNAT3
PLCB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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