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Article

High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis.

Oncotarget - 20 Oct 2015

Kao Hsiao-Wen, Liang D Cherng, Kuo Ming-Chung, Wu Jin-Hou, Dunn Po, Wang Po-Nan, Lin Tung-Liang, Shih Yu-Shu, Liang Sung-Tzu, Lin Tung-Huei, Lai Chen-Yu, Lin Chun-Hui, Shih Lee-Yung

Abstract excerpt

The mutational profiles of acute myeloid leukemia (AML) with partial tandem duplication of mixed-lineage leukemia gene (MLL-PTD) have not been comprehensively studied. We studied 19 gene mutations for 98 patients with MLL-PTD AML to determine the mutation frequency and clinical correlations. MLL-PTD was screened by reverse-transcriptase PCR and confirmed by real-time quantitative PCR. The mutational analyses were...

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methyltransferase 3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Histone-Lysine N-Methyltransferase

Share to Myeloid-Lymphoid Leukemia Protein

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Share to Tandem Repeat Sequences

Source

Open in PubMed Open full text

Identifiers

PMID: 26375248
DOI: 10.18632/oncotarget.5202
PMCID: PMC4741760

Genes

FLT3
IDH1
IDH2
NPM1
RUNX1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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