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Article

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia.

Genes, chromosomes & cancer - 1 Jul 2003

Steudel Christine, Wermke Martin, Schaich Markus, Schäkel Ulrike, Illmer Thomas, Ehninger Gerhard, Thiede Christian

Abstract excerpt

Partial tandem duplication (PTD) of the MLL gene and internal tandem duplication (ITD) of the juxtamembrane region of the FLT3 receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alterations have been associated with a poor prognosis. In our study, we analyzed the prevalence and the potential prognostic impact of these...

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Source

Identifiers

PMID: 12759922
DOI: 10.1002/gcc.10219

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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