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Article

ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.

PLoS pathogens - 1 Sept 2015

Shu Qian, Lennemann Nicholas J, Sarkar Saumendra N, Sadovsky Yoel, Coyne Carolyn B

Abstract excerpt

Interferon stimulated genes (ISGs) target viruses at various stages of their infectious life cycles, including at the earliest stage of viral entry. Here we identify ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2) as a gene upregulated by type I IFN treatment in a STAT1-dependent manner. ADAP2 functions as a GTPase-activating protein (GAP) for Arf6 and binds to phosphatidylinositol 3,4,5-trisphosphate...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26372645
DOI: 10.1371/journal.ppat.1005150
PMCID: PMC4570769

Genes

ADAP2
EEA1
LAMP1
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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