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Article

IRAV ( FLJ11286 ), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10

9 Jan 2017

Abstract excerpt

ABSTRACT Dengue virus (DENV) is a member of the genus Flavivirus and can cause severe febrile illness. Here, we show that FLJ11286, which we refer to as IRAV, is induced by DENV in an interferon-dependent manner, displays antiviral activity against DENV, and localizes to the DENV replication complex. IRAV is an RNA binding protein and localizes to cytoplasmic processing bodies (P bodies) in uninfected cells,...

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Identifiers

PMID: 27974568
DOI: 10.1128/jvi.01606-16

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