Article
Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody.
Nature communications - 15 Sept 2015
Ying Tianlei, Prabakaran Ponraj, Du Lanying, Shi Wei, Feng Yang, Wang Yanping, Wang Lingshu, Li Wei, Jiang Shibo, Dimitrov Dimiter S, Zhou Tongqing
Abstract excerpt
The MERS-CoV is an emerging virus, which already infected more than 1,300 humans with high (∼36%) mortality. Here, we show that m336, an exceptionally potent human anti-MERS-CoV antibody, is almost germline with only one somatic mutation in the heavy chain. The structure of Fab m336 in complex with the MERS-CoV receptor-binding domain reveals that its IGHV1-69-derived heavy chain provides more than 85% binding...
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