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Article

Epithelial to mesenchymal transition is associated with rapamycin resistance.

Oncotarget - 14 Aug 2015

Holder Ashley M, Akcakanat Argun, Adkins Farrell, Evans Kurt, Chen Huiqin, Wei Caimiao, Milton Denai R, Li Yisheng, Do Kim-Anh, Janku Filip, Meric-Bernstam Funda

Abstract excerpt

Rapamycin analogues have antitumor efficacy in several tumor types, however few patients demonstrate tumor regression. Thus, there is a pressing need for markers of intrinsic response/resistance and rational combination therapies. We hypothesized that epithelial-to-mesenchymal transition (EMT) co...

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Identifiers

PMID: 25944619
DOI: 10.18632/oncotarget.3669
PMCID: PMC4637301

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25944619-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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