Article
Epithelial vs myofibroblast differentiation in immortal rat lung cell lines--modulating effects of bleomycin.
Histochemistry and cell biology - 1 Dec 2005
Barth K, Reh J, Sturrock A, Kasper M
Abstract excerpt
Two alveolar epithelial cell lines R3/1 and L2 were screened by immunocytochemical and RT-PCR analysis of epithelial and mesenchymal/contractile marker proteins. R3/1 and L2 cells were tested for their sensitivity to bleomycin (BLM), an anticancer drug, which is proposed to induce changes in lung cell differentiation. Both epithelial cell lines exhibited a mixed phenotype consisting of epithelial (E-cadherin,...
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