Article

Microparticles derived from human erythropoietin mRNA-transfected mesenchymal stem cells inhibit epithelial-to-mesenchymal transition and ameliorate renal interstitial fibrosis

2020-07-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of chronic kidney disease (CKD) and its pathogenesis involves epithelial-to-mesenchymal transition (EMT) upon renal injury. Recombinant human erythropoietin (rhEPO) has been shown to display novel cytoprotective effects, in part by inhibiting transforming growth factor (TGF)-β1-in...

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Literature Corpus work: 299b38c6-d7d4-5ceb-b3ee-f4419ccdf993
DOI: 10.21203/rs.3.rs-18443/v3

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