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Exosomes of mesenchymal stem cells reduce cholesterol-induced hepatic fibrogenesis by inhibiting TGF-β/Smad3 signaling pathway in LX2 cells

2022-11-11

Abstract excerpt

<title>Abstract</title> <p>Dietary cholesterol is involved in the development of liver fibrosis, because free cholesterol accumulates in HSCs, can lead to Hepatic stellate cells (HSCs) sensitization to TGFβ. HSCs play a crucial role in the liver fibrosis process. This pathway can be targeted by anti-fibrotic therapies. MSCs-derived exosomes are known as the new mechanism of cell-to-cell communication which shows...

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Literature Corpus work
e1fe3e8a-93c6-5253-9bc9-29f8bda04f72
DOI
10.21203/rs.3.rs-2257652/v1
Open publication

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Exosomes of mesenchymal stem cells reduce cholesterol-induced hepatic fibrogenesis by inhibiting TGF-β/Smad3 signaling pathway in LX2 cellsDOI 10.21203/rs.3.rs-2257652/v1
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