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KMT2D regulates activation, localization, and integrin expression by T-cells

3 May 2024

Abstract excerpt

Individuals with Kabuki syndrome present with immunodeficiency; however, how pathogenic variants in the gene encoding the histone-modifying enzyme lysine methyltransferase 2D (KMT2D) lead to immune alterations remain poorly understood. Following up on our prior report of KMT2D-altered integrin expression in B-cells, we performed targeted analyses of KMT2D’s influence on integrin expression in T-cells throughout...

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Identifiers

PMID: 38765012
DOI: 10.3389/fimmu.2024.1341745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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