Article
Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Jan 2012
Masuyama Haruo, Yamada Masato, Kamei Yasuhiro, Fujiwara-Ishikawa Tomoko, Todo Takeshi, Nagahama Yoshitaka, Matsuda Masaru
Abstract excerpt
DMRT1, which is found in many vertebrates, exhibits testis-specific expression during the sexual differentiation period, suggesting a conserved function of DMRT1 in the testicular development of vertebrate gonads. However, functional analyses have been reported only in mammals. The current study focused on the Dmrt1 function in the teleost medaka, Oryzias latipes, which has an XX-XY sex determination system....
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