Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells via a GSK-3β-Dependent Mechanism.

Journal of cellular biochemistry - 1 Apr 2016

Shyu Hsin-Yi, Ko Chun-Jung, Luo Yu-Chen, Lin Hsin-Ying, Wu Shang-Ru, Lan Shao-Wei, Cheng Tai-Shan, Hu Shih-Hsiung, Lee Ming-Shyue

Abstract excerpt

Ketamine, a dissociative anesthetic, is misused and abused worldwide as an illegal recreational drug. In addition to its neuropathic toxicity, ketamine abuse has numerous effects, including renal failure; however, the underlying mechanism is poorly understood. The process called epithelial phenotypic changes (EPCs) causes the loss of cell-cell adhesion and cell polarity in renal diseases, as well as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics
Share to Glycogen Synthase Kinase 3 beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Junctions

Share to Madin Darby Canine Kidney Cells

Share to Occludin

Share to Snail Family Transcription Factors

Share to Twist-Related Protein 1

Share to Zonula Occludens-1 Protein

Source

Identifiers

PMID: 26365534
DOI: 10.1002/jcb.25372

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells via a GSK-3β-Dependent Mechanism.PMID 26365534Read ↗

Glutamatergic signaling maintains the epithelial phenotype of proximal tubular cells.Semantic proximity Read ↗

Tensin3 Is a Negative Regulator of Cell Migration and All Four Tensin Family Members Are Downregulated in Human Kidney CancerSemantic proximity Read ↗

Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis.Semantic proximity Read ↗

Malignant phenotype of renal cell carcinoma cells is switched by ukrain administration in vitro.Semantic proximity Read ↗

Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.Semantic proximity Read ↗

Norcantharidin inhibits renal interstitial fibrosis by blocking the tubular epithelial-mesenchymal transition.Semantic proximity Read ↗

Effect of pro-inflammatory interleukin-17A on epithelial cell phenotype inversion in HK-2 cells in vitro.Semantic proximity Read ↗

Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.Semantic proximity Read ↗

Epithelial phenotypic changes detect cyclosporine in vivo nephrotoxicity at a reversible stage.Semantic proximity Read ↗

Calreticulin Represses E-cadherin Gene Expression in Madin-Darby Canine Kidney Cells via SlugSemantic proximity Read ↗

p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial-to-mesenchymal transition.Semantic proximity Read ↗

PKB/SGK-resistant GSK-3 signaling following unilateral ureteral obstruction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.