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Article

Norcantharidin inhibits renal interstitial fibrosis by blocking the tubular epithelial-mesenchymal transition.

PloS one - 1 Jan 2013

Li Ying, Sun Yan, Liu Fuyou, Sun Lin, Li Jun, Duan Shaobin, Liu Hong, Peng Youming, Xiao Li, Liu Yuping, Xi Yiyun, You Yanhua, Li Hua, Wang Min, Wang Shuai, Hou Tao

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is thought to contribute to the progression of renal tubulointerstitial fibrosis. Norcantharidin (NCTD) is a promising agent for inhibiting renal interstitial fibrosis. However, the molecular mechanisms of NCTD are unclear. In this study, a unilateral ureteral obstruction (UUO) rat model was established and treated with intraperitoneal NCTD (0.1 mg/kg/day). The UUO rats...

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Identifiers

PMID: 23825538
DOI: 10.1371/journal.pone.0066356
PMCID: PMC3692527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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