Article
Glutamatergic signaling maintains the epithelial phenotype of proximal tubular cells.
Journal of the American Society of Nephrology : JASN - 1 Jun 2011
Bozic Milica, de Rooij Johan, Parisi Eva, Ortega Marta Ruiz, Fernandez Elvira, Valdivielso José M
Abstract excerpt
Epithelial-mesenchymal transition (EMT) contributes to the progression of renal tubulointerstitial fibrosis. The N-methyl-d-aspartate receptor (NMDAR), which is present in proximal tubular epithelium, is a glutamate receptor that acts as a calcium channel. Activation of NMDAR induces actin rearrangement in cells of the central nervous system, but whether it helps maintain the epithelial phenotype of the proximal...
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