Article
Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail.
Cell reports - 29 Sept 2015
Kugelman Jeffrey R, Kugelman-Tonos Johanny, Ladner Jason T, Pettit James, Keeton Carolyn M, Nagle Elyse R, Garcia Karla Y, Froude Jeffrey W, Kuehne Ana I, Kuhn Jens H, Bavari Sina, Zeitlin Larry, Dye John M, Olinger Gene G, Sanchez-Lockhart Mariano, Palacios Gustavo F
Abstract excerpt
MB-003, a plant-derived monoclonal antibody cocktail used effectively in treatment of Ebola virus infection in non-human primates, was unable to protect two of six animals when initiated 1 or 2 days post-infection. We characterized a mechanism of viral escape in one of the animals, after observation of two clusters of genomic mutations that resulted in five nonsynonymous mutations in the monoclonal antibody...
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