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Article

Monotherapy with antibody 1C3 partially protects Ebola virus-exposed macaques.

Journal of virology - 22 Jul 2025

Worwa Gabriella, Davis Carl W, Klim Sarah E, Turcinovic Jacquelyn, Agans Krystle N, Borisevich Viktoriya, Geisbert Joan B, Cross Robert W, Crane Anya, Holbrook Michael R, Sanchez-Lockhart Mariano, Kugelman Jeffrey R, Patino Galindo Juan A, Geisbert Thomas W, Ahmed Rafi, Kuhn Jens H, Saphire Erica Ollmann, Palacios Gustavo, Crozier Ian

Abstract excerpt

A cocktail of human monoclonal antibodies 1C3 and 1C11 previously protected macaques from a lethal exposure to either Ebola virus (EBOV) or Sudan virus (SUDV). 1C3 is of particular interest because its paratope strongly binds with unique stoichiometry to the glycoprotein head of several orthoebolaviruses, resulting in neutralization of EBOV and SUDV. Therefore, we evaluated the protective activity of 1C3 as a...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40492736
DOI: 10.1128/jvi.00296-25
PMCID: PMC12282081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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