Article
Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility.
Molecular neurobiology - 1 Sept 2016
Liu Guiyou, Liu Yongquan, Jiang Qinghua, Jiang Yongshuai, Feng Rennan, Zhang Liangcai, Chen Zugen, Li Keshen, Liu Jiafeng
Abstract excerpt
A rare TREM2 missense mutation (rs75932628-T) was reported to confer a significant Alzheimer's disease (AD) risk. A recent study indicated no evidence of the involvement of this variant in Parkinson's disease (PD). Here, we used the genetic and expression data to reinvestigate the potential association between TREM2 and PD susceptibility. In stage 1, using 10 independent studies (N = 89,157; 8787 cases and 80,370...
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