Article
Human TLR10 is an anti-inflammatory pattern-recognition receptor.
Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014
Oosting Marije, Cheng Shih-Chin, Bolscher Judith M, Vestering-Stenger Rachel, Plantinga Theo S, Verschueren Ineke C, Arts Peer, Garritsen Anja, van Eenennaam Hans, Sturm Patrick, Kullberg Bart-Jan, Hoischen Alexander, Adema Gosse J, van der Meer Jos W M, Netea Mihai G, Joosten Leo A B
Abstract excerpt
Toll-like receptor (TLR)10 is the only pattern-recognition receptor without known ligand specificity and biological function. We demonstrate that TLR10 is a modulatory receptor with mainly inhibitory effects. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production,...
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