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Article

The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice.

PloS one - 1 Jan 2015

Baldauf Christina, Jeschke Anke, Kanbach Vincent, Catala-Lehnen Philip, Baumhoer Daniel, Gerull Helwe, Buhs Sophia, Amling Michael, Nollau Peter, Harroch Sheila, Schinke Thorsten

Abstract excerpt

Osteosarcoma (OS), a highly aggressive primary bone tumor, belongs to the most common solid tumors in growing children. Since specific molecular targets for OS treatment remain to be identified, surgical resection combined with multimodal (neo-)adjuvant chemotherapy is still the only way to help respective individuals. We have previously identified the protein tyrosine phosphatase Rptpζ as a marker of terminally...

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Share to Bone Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Intercellular Signaling Peptides and Proteins

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Source

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Identifiers

PMID: 26360410
DOI: 10.1371/journal.pone.0137745
PMCID: PMC4567063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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