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Article

A new regulatory switch in a JAK protein kinase.

Proteins - 1 Feb 2011

Tsui Vickie, Gibbons Paul, Ultsch Mark, Mortara Kyle, Chang Christine, Blair Wade, Pulk Rebecca, Stanley Mark, Starovasnik Melissa, Williams David, Lamers Maria, Leonard Phillip, Magnuson Steven, Liang Jun, Eigenbrot Charles

Abstract excerpt

Members of the JAK family of protein kinases mediate signal transduction from cytokine receptors to transcription factor activation. Over-stimulation of these pathways is causative in immune disorders like rheumatoid arthritis, psoriasis, lupus, and Crohn's disease. A search for selective inhibit...

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Identifiers

PMID: 21117080
DOI: 10.1002/prot.22889

Genes

TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21117080-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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