Twin study reveals non-heritable immune perturbations in multiple sclerosis.

doi:10.1038/s41586-022-04419-4

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Article

Twin study reveals non-heritable immune perturbations in multiple sclerosis.

Nature - 1 Mar 2022

Ingelfinger Florian, Gerdes Lisa Ann, Kavaka Vladyslav, Krishnarajah Sinduya, Friebel Ekaterina, Galli Edoardo, Zwicky Pascale, Furrer Reinhard, Peukert Christian, Dutertre Charles-Antoine, Eglseer Klara Magdalena, Ginhoux Florent, Flierl-Hecht Andrea, Kümpfel Tania, De Feo Donatella, Schreiner Bettina, Mundt Sarah, Kerschensteiner Martin, Hohlfeld Reinhard, Beltrán Eduardo, Becher Burkhard

Abstract excerpt

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system underpinned by partially understood genetic risk factors and environmental triggers and their undefined interactions1,2. Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs discordant for MS to dissect the influence of genetic predisposition and environmental factors. Using complementary...

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Identifiers

PMID: 35173329
DOI: 10.1038/s41586-022-04419-4
PMCID: PMC8891021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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