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Article

Inhibition of LtxA toxicity by blocking cholesterol binding with peptides.

Molecular oral microbiology - 1 Feb 2016

Brown A C, Koufos E, Balashova N V, Boesze-Battaglia K, Lally E T

Abstract excerpt

The leukotoxin (LtxA) produced by Aggregatibacter actinomycetemcomitans kills host immune cells, allowing the bacterium to establish an ecological niche in the upper aerodigestive tract of its human host. The interaction of LtxA with human immune cells is both complex and multifaceted, involving membrane lipids as well as cell-surface proteins. In the initial encounter with the host cell, LtxA associates with...

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Source

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Identifiers

PMID: 26352738
DOI: 10.1111/omi.12133
PMCID: PMC4712104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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