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Article

Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol.

The Journal of biological chemistry - 17 Apr 2009

Boesze-Battaglia Kathleen, Brown Angela, Walker Lisa, Besack Dave, Zekavat Ali, Wrenn Steve, Krummenacher Claude, Shenker Bruce J

Abstract excerpt

Induction of cell cycle arrest in lymphocytes after exposure to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is dependent upon the integrity of lipid membrane microdomains. In this study we further demonstrate that the association of Cdt with lymphocyte plasma membranes is dependent upon binding to cholesterol. Depletion of cholesterol resulted in reduced toxin binding, whereas...

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Identifiers

PMID: 19240023
DOI: 10.1074/jbc.M809094200
PMCID: PMC2667752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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