Article

Reactivating the complement system using peptidic bacterial labeling tag

2023-07-09

Abstract excerpt

The immune system plays a critical role in protecting the host against pathogens, including bacteria, viruses, and parasites. However, pathogens have evolved mechanisms to evade the immune system, for example by altering their surface proteins or by producing enzymes that can interfere with the immune response. These evasion strategies enable pathogens to escape detection and destruction by the immune system, whic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93956423-7540-500e-a24b-b53121ceb21c
DOI: 10.1101/2023.07.09.548267

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reactivating the complement system using peptidic bacterial labeling tagDOI 10.1101/2023.07.09.548267Read

Complement resistance mechanisms of Klebsiella pneumoniaeSemantic proximity Read

Hijacking Complement Regulatory Proteins for Bacterial Immune EvasionSemantic proximity Read

Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5Semantic proximity Read

The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel TherapeuticsSemantic proximity Read

Engineered antibodies targeted to bacterial surface integrate effector functions with toxin neutralization to provide superior efficacy against bacterial infectionsSemantic proximity Read

Evasion of pathogens by avoiding recognition or eradication by complement, in part via molecular mimicrySemantic proximity Read

Protease-dependent mechanisms of complement evasion by bacterial pathogensSemantic proximity Read

Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of <i>Klebsiella pneumoniae</i>Semantic proximity Read

Bacterial complement evasionSemantic proximity Read

Complement Evasion Strategies of Human Pathogenic BacteriaSemantic proximity Read

Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation.Semantic proximity Read

Complement evasion of pathogens: Common strategies are shared by diverse organismsSemantic proximity Read