Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells

22 Nov 2016

Abstract excerpt

Toxoplasma gondii is the most common protozoan parasitic infection in man. Gamma interferon (IFNγ) activates haematopoietic and non-haematopoietic cells to kill the parasite and mediate host resistance. IFNγ-driven host resistance pathways and parasitic virulence factors are well described in mice, but a detailed understanding of pathways that kill Toxoplasma in human cells is lacking. Here we show, that contrary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cytomegalovirus and herpesvirus research
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27875583
DOI: 10.1371/journal.ppat.1006027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human CellsPMID 27875583Read ↗

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human CellsSemantic proximity Read ↗

Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell deathSemantic proximity Read ↗

Cell Death of Gamma Interferon-Stimulated Human Fibroblasts upon Toxoplasma gondii Infection Induces Early Parasite Egress and Limits Parasite ReplicationSemantic proximity Read ↗

A Combination of Four Nuclear Targeted Effectors Protects <i>Toxoplasma</i> Against Interferon Gamma Driven Human Host Cell Death During Acute InfectionSemantic proximity Read ↗

How Toxoplasma and malaria parasites defy first, then exploit host autophagic and endocytic pathways for growthSemantic proximity Read ↗

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human CellsSemantic proximity Read ↗

Molecular Basis for Interferon-mediated Pathogen Restriction in Human CellsSemantic proximity Read ↗

Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous VacuolesSemantic proximity Read ↗

Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite lociSemantic proximity Read ↗

Strategies Developed by Toxoplasma gondii to Survive in the HostSemantic proximity Read ↗

Autophagy gene-dependent intracellular immunity triggered by interferon-γSemantic proximity Read ↗

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.