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Article

Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci

14 Dec 2023

Abstract excerpt

ABSTRACT Autophagy contributes to innate immunity by targeting intracellular pathogens for elimination. Previous studies identified a non-canonical autophagy pathway that controls Toxoplasma gondii infection in a strain-dependent manner in interferon gamma-activated human cells. Ubiquitination of unknown targets recruits adaptors and LC3 to the parasitophorous vacuole, leading to membrane envelopment and stunted...

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PMID: 38095418
DOI: 10.1128/mbio.02595-23

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