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Article

Role of Mouse and Human Autophagy Proteins in IFN-γ–Induced Cell-Autonomous Responses against <i>Toxoplasma gondii</i>

22 Feb 2014

Abstract excerpt

IFN-γ mediates cellular innate immunity against an intracellular parasite, Toxoplasma gondii, by inducing immunity-related GTPases such as p47 IFN-γ-regulated GTPases (IRGs) and p65 guanylate-binding proteins (GBPs), which also participate in antibacterial responses via autophagy. An essential autophagy protein, Atg5, was previously shown to play a critical role in anti-T. gondii cell-autonomous immunity....

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PMID: 24563254
DOI: 10.4049/jimmunol.1302822

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