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DNA methylation profiling of non-small cell lung cancer reveals a COPD-driven immune-related signature

8 Sept 2015

Abstract excerpt

INTRODUCTION: Non-small cell lung cancer (NSCLC) is a heterogeneous disorder consisting of distinct molecular subtypes each characterised by specific genetic and epigenetic profiles. Here, we aimed to identify novel NSCLC subtypes based on genome-wide methylation data, assess their relationship with smoking behaviour, age, COPD, emphysema and tumour histopathology, and identify the molecular pathways underlying...

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PMID: 26349763
DOI: 10.1136/thoraxjnl-2015-207288

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