Article

CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and <i>TP53</i> mutations

2020-07-17

Abstract excerpt

<h4>SUMMARY</h4> Immunotherapy is becoming a mainstay in the treatment of NSCLC. While tumor mutational burden (TMB) has been shown to correlate with response to immunotherapy, little is known about the relation of the baseline immune response with the tumor genotype. Here, we profiled 35 early stage NSCLC lesions using multiscale single cell sequencing. Unsupervised clustering identified in a subset of patients...

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Literature Corpus work: 2287cc2c-76ce-5d0a-b003-af441ebfe489
DOI: 10.1101/2020.07.16.207605

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