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Article

Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2014

Karlsson Anna, Jönsson Mats, Lauss Martin, Brunnström Hans, Jönsson Per, Borg Åke, Jönsson Göran, Ringnér Markus, Planck Maria, Staaf Johan

Abstract excerpt

PURPOSE: Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer remains unclear. EXPERIMENTAL DESIGN: Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25278450
DOI: 10.1158/1078-0432.CCR-14-1087

Genes

KEAP1
KRAS
SMARCA4
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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