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Article

Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes.

Journal of diabetes research - 1 Jan 2015

Tajbakhsh Samira, Aliakbari Kamelya, Hussey Damian J, Lower Karen M, Donato Anthony J, Sokoya Elke M

Abstract excerpt

Vascular dysfunction is an early feature of diabetic vascular disease, due to increased oxidative stress and reduced nitric oxide (NO) bioavailability. This can lead to endothelial cell senescence and clinical complications such as stroke. Cells can become senescent by shortened telomeres and oxidative stress is known to accelerate telomere attrition. Sirtuin 1 (SIRT1) has been linked to vascular health by...

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Source

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Identifiers

PMID: 26346823
DOI: 10.1155/2015/153829
PMCID: PMC4545169

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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