Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonclinical Development of BCG Replacement Vaccine Candidates

16 Apr 2013

Abstract excerpt

The failure of current Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccines, given to neonates to protect against adult tuberculosis and the risk of using these live vaccines in HIV-infected infants, has emphasized the need for generating new, more efficacious and safer replacement vaccines. With the availability of genetic techniques for constructing recombinant BCG (rBCG) strains containing well-defined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune responses and vaccinations
Share to Immunodeficiency and Autoimmune Disorders
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26343962
DOI: 10.3390/vaccines1020120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonclinical Development of BCG Replacement Vaccine CandidatesPMID 26343962Read ↗

Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memorySemantic proximity Read ↗

Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosisSemantic proximity Read ↗

Live Attenuated Vaccines against Tuberculosis: Targeting the Disruption of Genes Encoding the Secretory Proteins of MycobacteriaSemantic proximity Read ↗

BCG VaccinesSemantic proximity Read ↗

BCG Vaccines: Their mechanisms of attenuation and impact on safety and protective efficacySemantic proximity Read ↗

Genetic Modification of the BCG Vaccine to Overcome Its Limited Efficacy in Adults: A Specialized ReviewSemantic proximity Read ↗

Improving vaccines against tuberculosisSemantic proximity Read ↗

Manipulation of BCG vaccine: a double-edged swordSemantic proximity Read ↗

Dietary pyridoxine controls efficacy of vitamin B6-auxotrophic tuberculosis vaccine bacillus Calmette-Guérin ΔureC::hly Δpdx1 in mice.Semantic proximity Read ↗

Recombinant BCG to Enhance Its Immunomodulatory ActivitiesSemantic proximity Read ↗

How Virulence of <em>Listeria monocytogenes </em>Can Be Harnessed to Develop an Immunotherapeutic AgentSemantic proximity Read ↗

Crucial requirement for standardization during the development of novel recombinant BCG vaccines: Does the corresponding substrain background matter?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.