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Article

Impaired expansion of regulatory T cells in a neonatal thymectomy-induced autoimmune mouse model.

The American journal of pathology - 1 Nov 2015

Yamada Akiko, Ushio Aya, Arakaki Rieko, Tsunematsu Takaaki, Kudo Yasusei, Hayashi Yoshio, Ishimaru Naozumi

Abstract excerpt

Neonatal thymectomy in certain mouse strains is known to induce organ-specific autoimmunity due to impaired functions of T cells, including Foxp3(+) regulatory T (Treg) cells in the thymus. The precise mechanism underlying the induction of autoimmunity by neonatal thymectomy remains unclear. One possibility is that depletion of Treg cells breaks down peripheral tolerance. We examined the functions of Treg cells...

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Identifiers

PMID: 26343329
DOI: 10.1016/j.ajpath.2015.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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