[Increase of regulatory T cells in the lymph node of cathepsin L mutant mice].

Abstract excerpt

Regulatory CD4+CD25+Foxp3+ T cells (Treg) have been implicated in different pathologies including cancer, infections and autoimmune diseases and in the rejection of allogeneic organ transplantation. Thus, modulation of Treg activity has a great potential in the treatment of these pathologies. Herein, we evaluated the influence of cathepsin L (CTSL) on Treg homeostasis. CTSL mutant mice (CTSLnkt/nkt) showed a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Cathepsin L
• Share to Cell Proliferation