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Article

Tumor interstitial fluid promotes malignant phenotypes of lung cancer independently of angiogenesis.

Cancer prevention research (Philadelphia, Pa.) - 1 Nov 2015

Li Hong, Li Ganggang, Liu Linxin, Guo Zhenzhen, Ma Xiaofang, Cao Ning, Lin Haihong, Han Guang, Duan Yongjian, Du Gangjun

Abstract excerpt

Angiogenesis is necessary for cancer progression, but antiangiogenic therapy actually promotes tumor recurrence, progression, and metastasis. This study focused on the contribution of the tumor interstitial fluid (TIF) to lung cancer progression. TIF was isolated and quantified for 10 μg protein/mL. Malignant driver characteristics of TIF were examined by tumor-initiating cells (TIC), self-renewal,...

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Source

Identifiers

PMID: 26342025
DOI: 10.1158/1940-6207.CAPR-15-0242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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