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Article

Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration.

PloS one - 1 Jan 2015

Madhavan Lalitha, Daley Brian F, Davidson Beverly L, Boudreau Ryan L, Lipton Jack W, Cole-Strauss Allyson, Steece-Collier Kathy, Collier Timothy J

Abstract excerpt

The expression of soluble growth and survival promoting factors by neural precursor cells (NPCs) is suggested to be a prominent mechanism underlying the protective and regenerative effects of these cells after transplantation. Nevertheless, how and to what extent specific NPC-expressed factors contribute to therapeutic effects is not well understood. Using RNA silencing, the current study investigated the roles...

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Source

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Identifiers

PMID: 26340267
DOI: 10.1371/journal.pone.0137136
PMCID: PMC4560385

Genes

SHH
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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