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Article

The adult substantia nigra contains progenitor cells with neurogenic potential.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Aug 2002

Lie D Chichung, Dziewczapolski Gustavo, Willhoite Andrew R, Kaspar Brian K, Shults Clifford W, Gage Fred H

Abstract excerpt

In Parkinson's disease, progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SN) leads to debilitating motor dysfunction. One current therapy aims at exogenous cellular replacement of dopaminergic function by transplanting fetal midbrain cells into the striatum, the main projection area of the SN. However, results using this approach have shown variable success. It has been proposed...

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PMID: 12151543
PMCID: PMC6758128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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