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Enhanced neuronic differentiation of neural stem cells by SHH gene-engineered EMSCs co-culture in vitro

2023-02-24

Abstract excerpt

Spinal cord injury is a severe central nervous system disease. Neural crest-derived ectoderm mesenchymal stem cells (EMSCs) have become an important tool in treating SCI owing to their excellent neuronal differentiation efficiency and promising paracrine effects. Sonic hedgehog (shh) was proven to promote both the proliferation and chemotaxis of NSCs and induce their differentiation into mature neurons and the for...

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Literature Corpus work: a43677dd-3f9f-58b3-b3c2-7eec51fd0773
DOI: 10.21203/rs.3.rs-2618923/v1

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