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Article

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

PloS one - 1 Jan 2013

Lin Wan-chi, Schmidt Jeffrey W, Creamer Bradley A, Triplett Aleata A, Wagner Kay-uwe

Abstract excerpt

The Signal Transducer and Activator of Transcription 5 (Stat5) plays a significant role in normal hematopoiesis and a variety of hematopoietic malignancies. Deficiency in Stat5 causes impaired cytokine-mediated proliferation and survival of progenitors and their differentiated descendants along major hematopoietic lineages such as erythroid, lymphoid, and myeloid cells. Overexpression and persistent activation of...

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Identifiers

PMID: 23565285
DOI: 10.1371/journal.pone.0060902
PMCID: PMC3614894

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